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In their recent work, the team led by Uhlenhaut turned their attention to the hour metabolic rhythm of muscles. Building upon previous studies, the scientists studied the synthesis and breakdown of fats and proteins over 24 hours — an approach that might also be interesting for athletes.
Heinrich-Heine-Universität Düsseldorf
In collaboration with Italian and Austrian colleagues from the Venetian Institute of Molecular Medicine and the Universities of Padua, Graz, and Trieste the researchers identified certain processes that are switched on at night by the regulators of the internal clock: At the same time, opposing processes such as fatty acid oxidation and protein breakdown are throttled down, according the authors. These patterns are especially pronounced in the hours before awakening and are thought to prepare the muscles for the day ahead.
In the final step, the scientists investigated possible ways to intervene in these processes.
To this end, they examined mice lacking these master regulators. Without a circadian clock, the animals were leaner, with less fat and more muscle mass.
Universität Düsseldorf: Studying
Their hope is that it might be possible to counteract insulin resistance in type 2 diabetes or to stimulate energy use to combat obesity. Original Publication Dyar, K. Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
The Institute of Diabetes and Obesity IDO studies the diseases of the metabolic syndrome by means of systems biological and translational approaches on the basis of cellular systems, genetically modified mouse models and clinical intervention studies. It seeks to discover new signaling pathways in order to develop innovative therapeutic approaches for the personalized prevention and treatment of obesity, diabetes and their concomitant diseases.
The German Center for Diabetes Research DZD is a national association that brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications.
Environmental protection and social commitment
The aim is to develop novel strategies for personalized prevention and treatment of diabetes. As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching. Building on its year-tradition of scholarship, LMU covers a broad spectrum of disciplines, ranging from the humanities and cultural studies through law, economics and social studies to medicine and the sciences.
The know-how and creativity of LMU's academics form the foundation of the University's outstanding research record. Helmholtz - Gemeinschaft Deutscher Forschungszentren.